Burkitts Lymphoma Disease Essay - 3211 Words

Burkitt’s lymphoma is a very aggressive form of B-cell non-Hodgkin lymphoma. The disease is related with Epstein-Barr virus and was one of the first tumours shown to have a chromosomal translocation. The Burkitt’s lymphoma disease is the most common childhood cancer where malaria is predominantly an epidemic. About10% of all malignant diseases in children under 15 years of age. Disease is very common in those whose immune system is not functionally efficient. With the help of intensive chemotherapy, children are in better health. On the other hand, children in third world countries are not as aggressive in treatment of Burkitt’s lymphoma. The right prognosis helps doctors evaluate the initial steps of Burkitt’s lymphoma.†¦show more content†¦(1) The observation and description of the lymphoma named after Dennis Burkitt in 1964 was a major breakthrough in virology and in cancer research. It led to the discovery that all humans carry a DNA virus tha t can transform B lymphocytes, named after its discoverers Epstein-Barr-Virus, (EBV) , this is virus which causes glandular fever; however, the virus carrying state is mostly harmless. This is due to two main aspects of the complex host-virus and host-cell and virus interactions. According to Epstein The gene expressions strategy of the virus adjusts it to various cellular environments that together with our immune response establish a finely poised balance of the virus carrying state, limiting the proliferation of the virally infected cells. Activation of the c-myc ontogeny by chromosomal translocation is the key event in this malignancy. Burkitt lymphoma was called the Rosetta Stone of EBV biology, and the stalking horse of cancer research. (2) Points discussed in the reviews touch on the history of the discoveries of the lymphoma and of the virus, the expression types of the EBV encoded proteins in cells with latent infection, the pivotal role and functional consequences of the l g/myc translocation the success of immune surveillance, and the crippling of the major apoptotic pathways. (3) TheShow MoreRelatedBurkitt s Lymphom An Uncommon Form Of Non Hodgkin Lymphoma1040 Words   |  5 PagesBurkitt’s lymphoma is an uncommon form of non-Hodgkin’s lymphoma. In United States, the case rate during 2001-2009 period was 0.4 cases per 100,000 population according to NCI’s SEER statistical database.1 Burkitt’s lymphoma constitutes 0.4% of all the lymphoid tumor accounting for between 40 and 50% of childhood non-Hodgkin s lymphomas (NHLs) in non-endemic areas.2-4 The sporadic form in adults accounts for 1–2% of all adult lymphomas in western Europe and the United States.5 Burkitt’s lymphomaRead MoreEpstein Barr Virus ( Ebv )1416 Words   |  6 Pagesby Sir Michael Anthony Epstein and Ms. Yvonne Barr. They located it in a Burkitt lymphoma cell line. It was the first virus to be associated with cancer. Infection of Epstein-Barr (EBV) is extremely widespread. The National Institutes of Health estimates that roughly 95% of people carry the virus. The virus was later found to cause infectious mononucleosis. Mononucleosis has since been nicknamed the â€Å"kissing disease†. Transmission is spread orally, primarily through saliva. 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The heterogeneity arise, due to dysregulation in different stage of B-cell development, regulated by different transcription factors such as B-cell lymphoma 6 (BCL-6)[106-108]. Due to this clinical and biological diversity, DLBCL is categorized into two commonRead MoreDevelopment of a Lab-on-a-Chip Device to Detect DNA Double Strand Breaks in Situ793 Words   |  3 Pagescellular survival and function particularly in the case of erroneous DNA repair mechanisms. Indeed, many cancers bear oncogenic rearrangements, loss and/or amplification of genetic material. For example, the underlying cause of most cases of Burkitt’s lymphoma is a rearrangement involving the c-MYC gene, a proto-oncogene[2]. Therefore, accumulation of DSBs and/or defective DNA repair system is a major threat and its detection can bring large value in the prediction of carcinogenesis. 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AIDS-related lymphoma is a very complex disease with many factors to consider. It is important to understand the origin of AIDS-related lymphoma. According to the article â€Å"AIDS-Related Malignancies,† AIDS-related lymphoma is believed to be causedRead MoreIdentify And Describe Three Groups Of Low G + C Gram Positive Bacteria1579 Words   |  7 PagesIdentify and describe three groups of low G+C Gram-positive bacteria. Clostridia: rod-shaped, obligate anaerobes, some form endospores, produce potent toxins that cause a variety of diseases in humans. Important in medicine industry (Botox oral plaque). Examples of clostridia include C. tetani (cause tetanus), C. perfringens ( causes gangrene), C. botulinum ( causes botulism) and C. difficle (severe diarrhea). 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